Effect of Glutamine on Apoptosis-inducing Factor Expression and Apoptosis of Glomerular Parietal Epithelial Cells of Cisplatin-exposed Rats

AIM: This study analyzed the nephroprotective effect by examining apoptosis-inducing factor (AIF) expression and apoptosis rate in glomerular parietal epithelial cell of cisplatin-exposed rats. METHODS: Samples consisted 30 rats (divided into 3 groups: Group P0 received no treatment, group P1 a cisplatin injection on 7th day, P2 glutamine days 1–7 day). After 72 h, tissue samples were immunohistochemically processed. AIF was measured an Allred score. The apoptotic cells/field view. Statistical analysis carried out using JASP Statistics ver. 0.12.0 (p < 0.05). RESULTS: values are follows: = 4.89 ± 0.418, 6.14 0.685, 4.95 0.530. Kruskal–Wallis test result showed significant difference 0.05) between groups Dunn’s post hoc P2, but P2. Meanwhile, as 24.3 9.821, 123.6 16.008, 77.2 10.644. groups, P1, CONCLUSION: cells rat has decreased after treatment.